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Zonisamide-13C6

Cat.No.:HY-B0124S2

Synonyms:AD810-13C;CI912-13C

66

分?式:C???C?H?N?O?S

分?量:214.15

作?靶点:Isotope-LabeledCompounds;CarbonicAnhydrase;Apoptosis

作?通路:Others;MetabolicEnzyme/Protease;Apoptosis

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Zonisamide-13C6(AD810-13C6)是13C标记的Zonisamide.Zonisamide(AD810)是?种?服有效的碳酸酐

酶(carbonicanhydrase)抑制剂，对?类线粒体同?酶hCAII和hCAV的Ki值分别为35.2nM和20.6nM。

Zonisamide可通过抗细胞凋亡和上调MnSOD?平来发挥神经保护作?。Zonisamide还能增加Hrd1的表达

，从?改善AAC??的?脏功能。Zonisamide可?于癫痫、帕?森和?脏肥?的研究。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.