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YJZ5118
Cat.No.:HY-173273
CASNo.:3031861-18-1
分?式:C??H??N?O?
分?量:620.79
作?靶点:CDK
作?通路:CellCycle/DNADamage
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性YJZ5118是?种CDK12/13抑制剂，对抑制CDK12和CDK13的IC50值分别为39.5nM和26.4nM。YJZ5118
可通过诱导DNA损伤和细胞凋亡(Apoptosis)，抑制肿瘤细胞增殖，与Akt抑制剂有协同效应。YJZ5118可?
于癌症领域的研究[1]。
IC50TargetCDK12CDK13
REFERENCES
[1].YangJ,etal.DiscoveryofYJZ5118:APotentandHighlySelectiveIrreversibleCDK12/13InhibitorwithSynergisticEffectsin
CombinationwithAktInhibition.JMedChem.2025Mar27;68(6):6718-6734.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
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1/1MasterofBioactiveMolecules—您?边的抑制剂?师