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Inhibitors?ScreeningLibraries?Proteins

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Empagliflozin-13C6

Cat.No.:HY-15409S1

Synonyms:BI10773-13C6

分?式:C????C?H??ClO?

分?量:456.87

作?靶点:Isotope-LabeledCompounds

作?通路:Others

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Empagliflozin-13C6(BI10773-13C6)是13C标记的Empagliflozin.Empagliflozin(BI10773)是?种选择性钠

葡萄糖协同转运蛋?-2(SGLT-2)抑制剂，抑制?SGLT-2的IC50为3.1nM[1]。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.