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Inhibitors?ScreeningLibraries?Proteins

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Binimetinib-d4

Cat.No.:HY-15202S3

CASNo.:2890696-60-1

Synonyms:MEK162-d;ARRY-162-d;ARRY-438162-d

444

分?式:C??H??D?BrF?N?O?

分?量:445.25

作?靶点:Isotope-LabeledCompounds;Autophagy;MEK

作?通路:Others;Autophagy;MAPK/ERKPathway

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Binimetinib-d4(MEK162-d4)是氘代标记的Binimetinib.Binimetinib(MEK162)是?服和选择性的MEK1/2抑

制剂，Binimetinib(MEK162)抑制MEK，IC50为12nM。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharma