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Tranexamicacid-13C6

Cat.No.:HY-B0149S2

Synonyms:Cyclocapron-13C6

分?式:C???C?H?NO?

分?量:153.09

作?靶点:Isotope-LabeledCompounds;MMP;Mitophagy;IGF-1R;

AMPK

作?通路:Others;MetabolicEnzyme/Protease;Autophagy;Protein

TyrosineKinase/RTK;Epigenetics;PI3K/Akt/mTOR

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Tranexamicacid-13C6(Cyclocapron-13C6)是13C标记的Tranexamicacid.Tranexamicacid

(cyclocapron)，赖氨酸的环类似物，是?种具有?服活性的抗纤维蛋?溶解剂。Tranexamicacid减轻严重创

伤的影响，抑制尿激酶型纤溶酶原激活剂，改善?性皱纹，可?于??的研究[1][2][3][4][5]。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.

[2].PrudovskyI,etal.TranexamicacidsuppressesthereleaseofmitochondrialDNA,protectstheendothelialmonolayerandenh