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TIP48/49-IN-1
Cat.No.:HY-103702
CASNo.:1807337-58-1
分?式:C??H??ClN?O?
分?量:536.02
作?靶点:ProtonPump
作?通路:MembraneTransporter/IonChannel
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性TIP48/49-IN-1(CompoundB)是?种?服有效的特异性RUVBL1/2ATPase抑制剂，其对纯化的RUVBL1/2的
IC50为59nM。TIP48/49-IN-1影响DNA复制过程，导致S期停滞。TIP48/49-IN-1诱导细胞凋亡(
apoptosis)。TIP48/49-IN-1抑制肿瘤?长，并增强??细胞肺癌细胞(NSCLC)的放射敏感性[1]。
REFERENCES
[1].YenerallP,etal.RUVBL1/RUVBL2ATPaseActivityDrivesPAQosomeMaturation,DNAReplicationandRadioresistanceinLung
Cancer.CellChemBiol.2020Jan16;27(1):105-121.e14.
McePdfHeight
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1/1MasterofBioactiveMolecules—您?边的抑制剂?师