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Sirtuinmodulator8
Cat.No.:HY-173463
CASNo.:925437-38-3
分?式:C??H??N?OS
分?量:483.59
作?靶点:Sirtuin
作?通路:CellCycle/DNADamage;Epigenetics
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性Sirtuinmodulator8是?种沉默调节蛋?(sirtuin)调节剂，能够激活Sirtuin的活性。Sirtuinmodulator8显
著下调单核细胞趋化蛋?-1(MCP-1)的表达，并上调成纤维细胞?长因?21(FGF21)的表达。Sirtuin
modulator8调控炎症和代谢相关基因的表达，展现出研究代谢性疾病(如糖尿病、肥胖)和炎症性疾病的潜?
[1]。
体外研究Sirtuinmodulator8(Compound2)(2μM)causesasignificantdecreaseinMCP-1expressioninahuman
leukocyte(WBC)model,indicatingitspotentialtoinhibitinflammatoryresponses[1].
REFERENCES
[1].OlivierBoss,etal.Biomarkersofsirtuinactivityandmethodsofusethereof.WO2008115518A2.US.2008-09-25
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
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