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文件名称：Atomoxetine-d7-Tomoxetine-d-sub-7-sub-生命科学试剂-MCE.pdf
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文档摘要

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Inhibitors?ScreeningLibraries?Proteins

www.MedChemE

Atomoxetine-d7

Cat.No.:HY-107370S

CASNo.:919104-07-7

Synonyms:Tomoxetine-d;(R)-Tomoxetine-d

77

分?式:C??H??D?NO

分?量:262.4

作?靶点:Isotope-LabeledCompounds;SerotoninTransporter;Sodium

Channel

作?通路:Others;NeuronalSignaling;MembraneTransporter/Ion

Channel

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Atomoxetine-d7(Tomoxetine-d7)是氘代标记的Atomoxetine.Atomoxetine(Tomoxetine)是?种选择性去

甲肾上腺素再摄取抑制剂(noradrenalinereuptake)，去甲肾上腺素(NE)、5-羟?胺(5-HT)和多巴胺(DA)转运

体的Ki值分别为5、77和1451nM。Atomoxetine(Tomoxetine)可以增加PFC中DAEX和NEEX，从?增强

?茶酚胺能神经传递。Atomoxetine(Tomoxetine)是?种有效的Na+通道阻断剂(VGSCs)。Atomoxetine

(Tomoxetine)可?于注意?缺陷多动障碍(ADHD)的研究。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,e