Hotline:400-820-3792
Inhibitors?ScreeningLibraries?Proteins
www.MedChemE
NLRP3-IN-76
Cat.No.:HY-170218
分?式:C??H??N?O?
分?量:338.32
作?靶点:NOD-likeReceptor(NLR);InterleukinRelated;NF-κB;NO
Synthase
作?通路:Immunology/Inflammation;NF-κB
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性NLRP3-IN-76是?种具有?服活性的NLRP3抑制剂。NLRP3-IN-76可抑制NO的产?以及促炎细胞因?(
iNOS、IL-6、IL-1β和TNFα)的mRNA?平。NLRP3-IN-76通过抑制NLRP3炎症?体和NF-κB信号通路的
激活发挥抗炎作?。NLRP3-IN-76可改善DSS(HY-116282C)诱发的结肠炎，并可?于炎症性肠病(IBD)的研
究[1]。
体外研究NLRP3-IN-76(CompoundST12)(10μM,24h)inhibitsnitricoxide(NO)production(52.67%)inLPSinduced
RAW264.7cells[1].
NLRP3-IN-76(10μM,24h)inhibitsmRNAlevelsofproinflammatorycytokinesinLPS-stimulatedRAW264.7
cells,suchasinducibleNOsynthase(iNOS),IL-6,IL-1βandTNF-α[1].
NLRP3-IN-76(2.5-10μM,24h)inhibitsNLRP3inflammasomeactivationandNF-κBsignalingpathwayin
LPS-stimulatedRAW264.7cells[1].
RT-PCR[1]
CellLine:LPS(0.1μg/mL)inducedRAW264.7cells
Concentration:2.5,10μM
IncubationTime:24h