Hotline:400-820-3792

Inhibitors?ScreeningLibraries?Proteins

www.MedChemE

Antibacterialsynergist3

Cat.No.:HY-173270

分?式:C??H??N?O?S

分?量:352.41

作?靶点:Bacterial

作?通路:Anti-infection

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Antibacterialsynergist3是双效?物膜(biofilm)抑制剂(PAO1的IC50:0.40μM和PA14的IC50:1.45μ

M)。Antibacterialsynergist3可通过抑制群体感应(QS)系统降低毒?产?并诱导铜绿假单胞菌PAO1发?铁

缺乏。Antibacterialsynergist3可增强??伤?感染模型中Tobramycin(HY-B0441)和Ciprofloxacin(HY-

B0356)的疗效。Antibacterialsynergist3可?于铜绿假单胞菌感染的研究。

体外研究Antibacterialsynergist3(compoundJH21)(0.15625-2.5μM)reducesthebiofilmformationrateofP.

aeruginosaPAO1inaconcentration-dependentmanner[1].

Antibacterialsynergist3(0.3125-10μM)reducestheproductionofP.aeruginosavirulencefactorselastase

(43%)andpyocyanin(42%),anddecreasestheproductionofbiofilmmatrixexopolysaccharides(58%)[1].

Antibacterialsynergist3(0.3125-10μM)suppressesthefluorescenceofPAO1-lasB-gfpandPAO1-pqsA-gfp

strainsbuthasnoeffectonthefluorescenceofPAO1-gfpanditsgrowth,indicatingthatitinhibitsboththelas

andpqssystems