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Inhibitors?ScreeningLibraries?Proteins
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P1D-34
Cat.No.:HY-171334A
分?式:C??H??ClN?O?S
分?量:835.45
作?靶点:PROTACs;PIN1;CDK;Akt;c-Myc;Apoptosis;Reactive
OxygenSpecies
作?通路:PROTAC;PI3K/Akt/mTOR;CellCycle/DNADamage;
Apoptosis;Immunology/Inflammation;Metabolic
Enzyme/Protease;NF-κB
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性P1D-34是?种Pin1PROTAC降解剂，DC50值为177nM。P1D-34还下调Pin1的客体蛋?，例如Cyclin
D1、Rb、Mcl-1、Akt和c-Myc。P1D-34在?组急性髓系??病(AML)细胞系中均表现出抗增殖活性。P1D-
34通过释放活性氧(ROS)来诱导细胞DNA损伤和凋亡。粉?：PIN1配体(HY-171442A)，蓝?：CRBN配体(
HY-14658)，??：连接?(HY-W014883)。
REFERENCES
[1].ShiY,etal.DiscoveryofpotentPROTACdegradersofPin1forthetreatmentofacutemyeloidleukemia.ChemSci.2024Feb
28;15(13):5027-5035.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
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