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Inhibitors?ScreeningLibraries?Proteins

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CDK2/FLT4/PDGFRA-IN-1

Cat.No.:HY-173124

分?式:C??H??N?O?

分?量:436.46

作?靶点:CDK;VEGFR;PDGFR;Apoptosis

作?通路:CellCycle/DNADamage;ProteinTyrosineKinase/RTK;

Apoptosis

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性CDK2/FLT4/PDGFRA-IN-1(Compound4a)是CDK2/细胞周期蛋?A、FLT4(VEGFR3)和PDGFRA的有效抑制

剂，IC50分别为1.672、0.554和0.629μM。CDK2/FLT4/PDGFRA-IN-1对癌细胞表现出强效的抗增殖作?。

CDK2/FLT4/PDGFRA-IN-1还能诱导癌细胞凋亡(apoptosis)。

REFERENCES

[1].MardanehP,et,al.Design,synthesisandpharmacologicalevaluationof1,4-naphthoquinone-1,2,3-triazolehybridsasnewanticancer

agentswithmulti-kinaseinhibitoryactivity.SciRep.2025Feb24;15(1):6639.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

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