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Nitricoxideproduction-IN-2

Cat.No.:HY-173388

CASNo.:1019984-44-1

分?式:C??H??O?

分?量:344.4

作?靶点:Toll-likeReceptor(TLR);JNK;NF-κB;NOSynthase

作?通路:Immunology/Inflammation;MAPK/ERKPathway;NF-κB

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Nitricoxideproduction-IN-2(CompoundRacemic-11k)是TLR4,JNK和NF-κB的抑制剂。Nitricoxide

production-IN-2抑制LPS刺激的RAW264.7细胞NO?成，IC50值为23.2μM。Nitricoxideproduction-IN-

2通过抑制TLR4的表达，降低JNK的磷酸化，从?抑制NF-κB的活化，阻断炎症相关基因的转录，降低

iNOS和COX-2的表达，减少NO、PGE2、TNF-α等炎症介质的产?，从?发挥抗炎活性。Nitricoxide

production-IN-2有望?于炎性疾病的研究，如类风湿关节炎和各种炎性疾病[1]。

REFERENCES

[1].TangML,etal.Discoveryofnovelsesquistilbeneindanoneanaloguesaspotentanti-inflammatoryagents.EurJMedChem.2016May

4;113:63-74.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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