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LEQ803

Cat.No.:HY-171459

CASNo.:1211441-59-6

Synonyms:N-DesmethylRibociclib

分?式:C??H??N?O

分?量:420.51

作?靶点:DrugMetabolite;CytochromeP450

作?通路:MetabolicEnzyme/Protease

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性LEQ803(N-DesmethylRibociclib)是CDK4/6抑制剂Ribociclib(HY-15777)的药物代谢物，经CYP3A4代谢产

?。LEQ803在肿瘤领域具有潜在应?价值[1]。

REFERENCES

[1].JamesAD,etal.AnintegratedassessmentoftheADMEpropertiesoftheCDK4/6Inhibitorribociclibutilizingpreclinicalinvitro,invivo,

andhumanADMEdata.PharmacolResPerspect.2020Jun;8(3):e00599.

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1/1MasterofBioactiveMolecules—您?边的抑制剂?师