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1-Bromo-3-chloropropane

Cat.No.:HY-Y0840

CASNo.:109-70-6

分?式:C?H?BrCl

分?量:157.44

作?靶点:PROTACLinkers

作?通路:PROTAC

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性1-Bromo-3-chloropropane是?个PROTAClinker，可?于合成PROTACYN14-H(HY-173250)。YN14-H是?

种靶向KRASG12C的PROTAC降解剂。YN14-H可抑制NCI-H358和MIAPaCa-2细胞的?长(IC50值分别为

0.042和0.021μM，DC50值分别为28.9和18.1nM)。

REFERENCES

[1].ShiyangSun,etal.RationaldesignofVHL-recruitingKRASG12Cproteolysis-targetingchimerasbasedonmoleculardynamics

simulation.ChineseChemicalLetters.20February2025,110992.InPress,JournalPre-proof.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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