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文件名称：Pyridoxine-d2-Pyridoxol-d-sub-2-sub-生命科学试剂-MCE.pdf
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文档摘要

Hotline:400-820-3792

Inhibitors?ScreeningLibraries?Proteins

www.MedChemE

Pyridoxine-d2

Cat.No.:HY-B1328S2

CASNo.:5027-84-9

Synonyms:Pyridoxol-d2

分?式:C?H?D?NO?

分?量:171.19

作?靶点:Isotope-LabeledCompounds;EndogenousMetabolite;Keap1-

Nrf2

作?通路:Others;MetabolicEnzyme/Protease;NF-κB

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Pyridoxine-d2(Pyridoxol-d2)是氘代标记的Pyridoxine.Pyridoxine(Pyridoxol)是?种吡啶衍?物。

Pyridoxine作?于阿尔茨海默病细胞模型,通过Nrf-2/HO-1途径发挥抗氧化作?。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.

[2].LiC,etal.Pyridoxineexertsantiox