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Antiparasiticagent-26

Cat.No.:HY-173356

分?式:C??H??NO?

分?量:315.32

作?靶点:Parasite;ReactiveOxygenSpecies

作?通路:Anti-infection;Immunology/Inflammation;Metabolic

Enzyme/Protease;NF-κB

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Antiparasiticagent-26(Compound8)是?种抗寄??化合物，对Naegleriafowleri?长具有强效抑制作?，

IC50为22.87μM(滋养体阶段)和25.16μM(包囊阶段)。Antiparasiticagent-26通过诱导程序性细胞死亡

，包括胞质钙积累、线粒体膜电位崩溃、ATP合成抑制、ROS积累及染?质凝聚，来发挥抗寄??i活性。

Antiparasiticagent-26可?于原发性阿?巴脑膜脑炎(PAM)的研究[1]。

REFERENCES

[1].BenYoussefM,etal.Amoebicidalthymolanaloguesagainstbrain-eatingamoeba,Naegleriafowleri.BioorgChem.2025Mar

6;159:108346.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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