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Inhibitors?ScreeningLibraries?Proteins

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Antimalarialagent49

Cat.No.:HY-173312

分?式:C??H??F?N?O

分?量:530.48

作?靶点:Parasite

作?通路:Anti-infection

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Antimalarialagent49是?种?服抗疟化合物。Antimalarialagent49可抑制Pf3D7和PfK1菌株的?长(IC50

分别为0.84μM和0.4μM)。Antimalarialagent49具有抗疟活性，并抑制P.berghei肝阶段的发育。

Antimalarialagent49可?于疟原?感染的研究。

体外研究Antimalarialagent49(compound15k)(0.37-10μM,40h)inhibitsthedevelopmentofP.bergheiliverstage

(IC50:5.88μM)[1].

体内研究Antimalarialagent49(compound15k)(100mg/kg,p.o.,onceeverydayfor4d)inhibitsinhibitsthegrowthof

parasitesintheP.yoeliiN67infectedmousemodel[1].

AnimalModel:FemaleSwissmice(6-8-week-old,18±2g)wereintra-peritoneallyinoculatedwith

1x106P.yoeliiN67infectedredbloodcells(iRBCs)[1]

Dosage:100mg/kg

Administration:Oralgavage(p.o.),onceeverydayfor4d

Result:Inhibited42.55%ofparasitegrowthonthe7thdayand35.93%ofparasitegrowthonthe