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Balapiravir(Standard)

Cat.No.:HY-10443R

CASNo.:690270-29-2

Synonyms:Ro4588161(Standard);R1626(Standard)

分?式:C??H??N?O?

分?量:494.5

作?靶点:HCV;DNA/RNASynthesis

作?通路:Anti-infection;CellCycle/DNADamage

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Balapiravir(Standard)是Balapiravir的分析标准品。本产品?于研究及分析应?。Balapiravir(Ro4588161;

R1626)是具有?服活性的R1479(4-Azidocytidine)的前体，R1479是?种HCVRNA依赖性RNA聚合酶(

RdRp)的核苷类似物抑制剂。Balapiravir具有抗HCV活性。Balapiravir是?种点击化学试剂。它含有Azide

基团，可以和含有Alkyne基团的分?发?铜催化的叠氮-炔环加成反应（CuAAc)。它还可以和含有DBCO或

BCN基团的分?发?环张?驱动的炔-叠氮环加成反应(SPAAC)。

REFERENCES

[1].NguyenNM,etal.Arandomized,double-blindplacebocontrolledtrialofbalapiravir,apolymeraseinhibitor,inadultdenguepatients.J

InfectDis.2013May1;207(9):1442-1450.

[2].NelsonDR,etal.Balapiravirpluspeginterferonalfa-2a(40KD)/ribavirininarandomizedtrialofhepatitisCgenotype1patients.Ann

Hepatol.2012Jan-Feb;11(1)