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Inhibitors?ScreeningLibraries?Proteins

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Elvitegravir-13C6

Cat.No.:HY-14740S2

Synonyms:GS-9137-13C;JTK-303-13C;D06677-13C

666

分?式:C????C?H??ClFNO?

分?量:450.82

作?靶点:Isotope-LabeledCompounds;HIVIntegrase;HIV

作?通路:Others;MetabolicEnzyme/Protease;Anti-infection

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Elvitegravir-13C6(GS-9137-13C6)是13C标记的Elvitegravir.Elvitegravir(GS-9137;JTK-303;D06677)是?

种HIVintegrase抑制剂，作?于HIV-1IIIB，HIV-2EHO和HIV-2ROD，IC50分别为0.7nM，2.8nM和1.4

nM。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitut