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Inhibitors?ScreeningLibraries?Proteins

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C-021dihydrochloride(Standard)

Cat.No.:HY-103364AR

CASNo.:1784252-84-1

分?式:C??H??Cl?N?O?

分?量:540.57

作?靶点:CCR

作?通路:GPCR/GProtein;Immunology/Inflammation

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性C-021(dihydrochloride)(Standard)是C-021(dihydrochloride)的分析标准品。本产品?于研究及分析应?。

C-021dihydrochloride是有效的CC趋化因?受体4(CCR4)拮抗剂。C-021dihydrochloride有效抑制?和?

?的功能趋化性，IC50分别为140nM和39nM。C-021dihydrochloride以IC50为18nM来有效阻??

CCL22衍?的[35S]GTPγS与受体结合。

REFERENCES

[1].YokoyamaK,etal.PotentandorallybioavailableCCR4antagonists:Synthesisandstructure-activityrelationshipstudyof2-

aminoquinazolines.BioorgMedChem.2009Jan1;17(1):64-73.

[2].MatthewMcMillin,etal.NeuronalCCL2isupregulatedduringhepaticencephalopathyandcontributestomicrogliaactivationand

neurologicaldecline.JNeuroinflammation.2014Jul10;11:121.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.