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UNC6535
Cat.No.:HY-168992
分?式:C??H??N?O?
分?量:460.66
作?靶点:HistoneMethyltransferase
作?通路:Epigenetics
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性UNC6535是?种有效且可逆的SETDB1三Tudor结构域(3TD)配体，IC50值为3.4μM。UNC6535同时占据
TD2和TD3读取器结合位点。UNC6535对SETDB1甲基转移酶活性有较弱的抑制作?，抑制全长蛋?的IC50
值为84μM。UNC6535对3TD缺乏选择性，也可能与SET结构域相互作?。
REFERENCES
[1].UguenM,et,al.PotentandselectiveSETDB1covalentnegativeallostericmodulatorreducesmethyltransferaseactivityincells.Nat
Commun.2025Feb24;16(1):1905.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
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