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Tiagabine-d6

Cat.No.:HY-B0696S

CASNo.:1217672-34-8

Synonyms:NO050328-d;NO328-d;TGB-d

666

分?式:C??H??D?NO?S?

分?量:381.58

作?靶点:Isotope-LabeledCompounds;GABAReceptor

作?通路:Others;MembraneTransporter/IonChannel;Neuronal

Signaling

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Tiagabine-d6(NO050328-d6)是氘代标记的Tiagabine.Tiagabine(NO050328)是?种有效、选择性的GABA

reuptake抑制剂，为抗惊厥剂；在突触体、神经元和神经胶质中，能够抑制[3H]GABA的重摄取，IC50值分

别为67，446和182nM[1]。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].R