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Inhibitors?ScreeningLibraries?Proteins

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Tasquinimod(Standard)

Cat.No.:HY-10528R

CASNo.:254964-60-8

Synonyms:ABR-215050(Standard)

分?式:C??H??F?N?O?

分?量:406.36

作?靶点:HDAC

作?通路:CellCycle/DNADamage;Epigenetics

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Tasquinimod(Standard)是Tasquinimod的分析标准品。本产品?于研究及分析应?。Tasquinimod是?种?

服抗?管?成剂，有潜??于去势抵抗性前列腺癌的研究。Tasquinimod与HDAC4Zn2+结合结构域结合的

Kd值为10-30nM。Tasquinimod也是?种S100A9抑制剂。

IC50TargetKd:10-30nM(HDAC4)[1]

REFERENCES

[1].IsaacsJT,etal.TasquinimodIsanAllostericModulatorofHDAC4survivalsignalingwithinthecompromisedcancermicroenvironment.

CancerRes.2013Feb15;73(4):1386-99.

[2].IsaacsJT,etal.Anti-cancerpotencyoftasquinimodisenhancedviaalbumin-bindingfacilitatingincreaseduptakeinthetumor

microenvironment.Oncotarget.2014Sep30;5(18):8093-106.

[3].OlssonA,etal.Tasquinimod(ABR-215050),aquinoline-3-carboxamideanti-angiogenicagent,modulatestheexpressionof

thrombospondin-1inhumanprostat