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文件名称：Selegiline-d5-hydrochloride-Deprenyl-d-sub-5-sub-hydrochloride-生命科学试剂-MCE.pdf
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Inhibitors?ScreeningLibraries?Proteins

www.MedChemE

Selegiline-d5hydrochloride

Cat.No.:HY-14199S

CASNo.:1217705-21-9

Synonyms:Deprenyl-dhydrochloride;(-)-Selegiline-dhydrochloride;(-)-

55

Deprenyl-dhydrochloride

5

分?式:C??H??D?ClN

分?量:228.77

作?靶点:Isotope-LabeledCompounds;MonoamineOxidase

作?通路:Others;NeuronalSignaling

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Selegiline-d5(hydrochloride)(Deprenyl-d5(hydrochloride))是氘代标记的Selegiline(hydrochloride).

Selegiline(Deprenyl)hydrochloride是?种有效、选择性和不可逆的MAO-B抑制剂，IC50值为51nM。

Selegilinehydrochloride对MAO-B的选择性?MAO-A?450倍(IC50=23μM)。Selegilinehydrochloride

可?于帕?森?病、阿尔茨海默病和重度抑郁症的研究。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].Russak