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S8849-1-d4freebase

Cat.No.:HY-166341S

CASNo.:1330822-91-7

Synonyms:TianeptinemetaboliteMC5-d4

分?式:C??H??D?ClN?O?S

分?量:412.92

作?靶点:Isotope-LabeledCompounds;DrugMetabolite

作?通路:Others;MetabolicEnzyme/Protease

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性S8849-1-d4(freebase)(TianeptinemetaboliteMC5-d4)是氘代标记的S8849-1(freebase).S8849-1(free

base)(TianeptinmetaboliteMC5)是?种存在于?浆中的Tianeptine(HY-90003)代谢物。S8849-1(free

base)在??体内的平均消除半衰期为7.53?时。S8849-1(freebase)有望?于抗抑郁剂的研究[1][2]。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutionon