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(RS)-Butyryltimolol(Standard)

Cat.No.:HY-102032AR

CASNo.:2320274-78-8

分?式:C??H??N?O?S

分?量:386.51

作?靶点:AdrenergicReceptor

作?通路:GPCR/GProtein;NeuronalSignaling

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性(RS)-Butyryltimolol(Standard)是(RS)-Butyryltimolol的分析标准品。本产品?于研究及分析应?。(RS)-

Butyryltimolol是Butyryltimolol的消旋体。Butyryltimolol是Timolol的有效前体。Timolol可?于研究青光

眼，但难于透过?膜，Timolol化学结构修饰后得到Butyryltimolol，透过眼?膜的能?增强，进?眼球后

，经酶?解再?成Timolol?起作?[1]。Butyryltimolol是?种β-肾上腺素能(β-adrenergic)阻滞剂[2]。

REFERENCES

[1].ChangSC,etal.Relativeeffectivenessofprodrugandviscoussolutionapproachesinmaximizingtheratioofoculartosystemic

absorptionoftopicallyappliedtimolol.ExpEyeRes.1988Jan;46(1):59-69.

[2].PotterDE,etal.Ocularandcardiacbeta-antagonismbytimololprodrugs,timololandlevobunolol.CurrEyeRes.1988Aug;7(8):755-9.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.