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Propylpyrazoletriol(Standard)

Cat.No.:HY-100689R

CASNo.:263717-53-9

Synonyms:PPT(Standard)

分?式:C??H??N?O?

分?量:386.44

作?靶点:EstrogenReceptor/ERR

作?通路:VitaminDRelated/NuclearReceptor

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Propylpyrazoletriol(Standard)是Propylpyrazoletriol的分析标准品。本产品?于研究及分析应?。Propyl

pyrazoletriol(PPT)是?种选择性的雌激素受体α(ERα)激动剂。Propylpyrazoletriol(PPT)对ERα的相对

结合亲和?(ERα:49%)是雌激素受体β(ERβ:0.12%)的410倍[1]。

IC50TargetEstrogenreceptoralpha[1]

REFERENCES

[1].InfluenceofcellularERalpha/ERbetaratioontheERalpha-agonistinducedproliferationofhumanT47Dbreastcancercells.

[2].StaufferSR,etal.Pyrazoleligands:structure-affinity/activityrelationshipsandestrogenreceptor-alpha-selectiveagonists.JMedChem.

2000Dec28;43(26):4934-47.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.