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Nevirapine-d8

Cat.No.:HY-10570S2

CASNo.:1051418-86-0

Synonyms:BI-RG587-d;NSC641530-d;NVP-d

888

分?式:C??H?D?N?O

分?量:274.35

作?靶点:Isotope-LabeledCompounds;ReverseTranscriptase;

Parasite;HIV

作?通路:Others;Anti-infection

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Nevirapine-d8(BI-RG587-d8)是氘代标记的Nevirapine.Nevirapine(BI-RG587)是?于研究HIV/AIDS的

HIV-1逆转录酶?核苷抑制剂，Ki值为270μM。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.

[2].EricksonDA,etal.CharacterizationoftheinvitrobiotransformationoftheHIV-1reversetranscriptaseinhibitornevirapinebyhuman

hepaticcytochromesP-450.DrugMetabD