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Inhibitors?ScreeningLibraries?Proteins

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Moxonidine-d3

Cat.No.:HY-B0374S2

Synonyms:BDF5895-d3

分?式:C?H?D?ClN?O

分?量:244.7

作?靶点:Isotope-LabeledCompounds;ImidazolineReceptor

作?通路:Others;NeuronalSignaling

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Moxonidine-d3(BDF5895-d3)是氘代标记的Moxonidine.Moxonidine(BDF5895)是咪唑啉1型受体（I1-R）选

择性激动剂，为降压剂。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.

[2].Schafer,U.,etal.,Presynapticeffectsofmoxonidineinisolatedbufferperfusedrathearts:roleofimidazoline-1receptorsandalpha2-

adrenoceptors.JPharmacolExpTher,