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Inhibitors?ScreeningLibraries?Proteins
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MLN8054(Standard)
Cat.No.:HY-10180R
CASNo.:869363-13-3
分?式:C??H??ClF?N?O?
分?量:476.86
作?靶点:AuroraKinase
作?通路:CellCycle/DNADamage;Epigenetics
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性MLN8054(Standard)是MLN8054的分析标准品。本产品?于研究及分析应?。MLN8054是?效，选择性
，有?服活性的极光激酶(auroraA)抑制剂，IC50值为4nM。
IC50TargetIC50:4nM(AuroraA),172nM(AuroraB)[1]
REFERENCES
[1].ManfrediMG,etal.AntitumoractivityofMLN8054,anorallyactivesmall-moleculeinhibitorofAuroraAkinase.ProcNatlAcadSciUS
A.2007Mar6;104(10):4106-11.
[2].HuckJJ,etal.MLN8054,aninhibitorofAuroraAkinase,inducessenescenceinhumantumorcellsbothinvitroandinvivo.MolCancer
Res.2010Mar;8(3):373-84.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
Forresearchuseonly.
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