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Mirabegron-d5

Cat.No.:HY-14773S3

CASNo.:1258889-45-0

Synonyms:YM178-d5

分?式:C??H??D?N?O?S

分?量:401.54

作?靶点:Isotope-LabeledCompounds;AdrenergicReceptor

作?通路:Others;GPCR/GProtein;NeuronalSignaling

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Mirabegron-d5(YM178-d5)是氘代标记的Mirabegron.Mirabegron是?种选择性的肾上腺素受体(β3-

adrenoceptor)激动剂，EC50为22.4nM。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.

[2].TakasuT,etal.Effectof(R)-2-(2-aminothiazol-4-yl)-4-{2-[(2-hydroxy-2-phenylethyl)amino]ethyl}acetani