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Inhibitors?ScreeningLibraries?Proteins

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Ketanserintartrate(Standard)

Cat.No.:HY-10562AR

CASNo.:83846-83-7

Synonyms:R41468tartrate(Standard)

分?式:C??H??FN?O?

分?量:545.51

作?靶点:5-HTReceptor;PotassiumChannel;Autophagy

作?通路:GPCR/GProtein;NeuronalSignaling;Membrane

Transporter/IonChannel;Autophagy

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Ketanserin(tartrate)(Standard)是Ketanserin(tartrate)的分析标准品。本产品?于研究及分析应?。

Ketanserin(R41468)tartrate是?种选择性的5-HT2receptor拮抗剂。Ketanserintartrate也抑制hERG电流

(IhERG)，IC50为0.11μM，这种作?具有浓度依赖性。

IC50TargetIC50:0.11μM(hERGcurrent)[1]

IC50:152±23μM(5-HTreceptor)[2]

REFERENCES

[1].TangQ,etal.The5-HT2antagonistKetanserinisanopenchannelblockerofhumancardiacether-à-go-go-relatedgene(hERG)

potassiumchannels.BrJPharmacol.2008Oct;155(3):365-73.

[2].KhanN,etal.Investigationofcyclooxygenaseandsignalingpathwaysinvolved