Hotline:400-820-3792
Inhibitors?ScreeningLibraries?Proteins
www.MedChemE
HDAC-IN-89
Cat.No.:HY-173330
分?式:C??H??F?N?O?S?
分?量:575.69
作?靶点:HDAC
作?通路:CellCycle/DNADamage;Epigenetics
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性HDAC-IN-89是HDAC1(IC50:0.95nM)、HDAC2(IC50:0.86nM)、HDAC3(IC50:1.06nM)和HDAC8(IC50:
4.24nM)的抑制剂。HDAC-IN-89可阻断细胞周期和诱导细胞凋亡(apoptosis)。HDAC-IN-89具有抗肿瘤活性
。
IC50TargetHDAC1HDAC2HDAC3HDAC8
0.95nM(IC50)0.86nM(IC50)1.06nM(IC50)4.24nM(IC50)
HDAC6
1000nM(IC50)
体外研究HDAC-IN-89(Compound12)(0-10000nM,72h)showscytotoxicityagainstbothNCI-H1975(IC50:0.57μM)
andHT-29(IC50:0.17μM)cancercells,butshowssignificantlyreducedcytotoxicityagainstbothWRL-68
(IC50:2.6μM)andHEK293(IC50:1.0μM)normalcells[1].
HDAC-IN-89(250nM-1μM,48h)inducescellcyclearrestintheG0/G1phaseofHT-29cellsand
significantlypromotesapoptosisofearlyandlatecellsatthecorrespondingconcentrations[1].
HDAC-IN-89(0-40μM)hasasmallinhibitory