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Inhibitors?ScreeningLibraries?Proteins

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Famotidine-13C

Cat.No.:HY-B0377S1

Synonyms:MK-208-13C

分?式:C???CH??N?O?S?

分?量:338.44

作?靶点:Isotope-LabeledCompounds;HistamineReceptor

作?通路:Others;GPCR/GProtein;Immunology/Inflammation;Neuronal

Signaling

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Famotidine-13C(MK-208-13C)是13C标记的Famotidine.Famotidine(MK-208)是组胺H2受体拮抗剂，可抑

制胃液分泌。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.

[2].Inan,A.,etal.,EffectsofthehistamineH2receptorantagonistfamotidineonthehealingofcolonican