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Inhibitors?ScreeningLibraries?Proteins

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Elobixibat-d5

Cat.No.:HY-15790S

Synonyms:A3309-d;AZD7806-d

55

分?式:C??H??D?N?O?S?

分?量:700.92

作?靶点:Isotope-LabeledCompounds;InterleukinRelated;Apical

Sodium-DependentBileAcidTransporter;TNFReceptor

作?通路:Others;Immunology/Inflammation;MembraneTransporter/Ion

Channel;Apoptosis

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Elobixibat-d5(A3309-d5)是氘代标记的Elobixibat.Elobixibat(A3309;AZD7806)是?种?服有效的Apical

Sodium-DependentBile(IBAT)抑制剂，IC50值分别为0.53nM(?类IBAT)，0.13nM(??IBAT)，5.8nM(

?类IBAT)。Elobixibat可降低LDL胆固醇，增加?清GLP-1，促进结肠运动，并具有治疗代谢综合征的潜?

。Elobixibat可?于便秘、?脂异常、?酒精性肝炎和肝脏肿瘤的研究[1][2][3]。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdev