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文件名称：Donepezil-d7-E2020-d-sub-7-sub-free-base-生命科学试剂-MCE.pdf
文件大小：458.45 KB
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更新时间：2025-05-21
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文档摘要

Hotline:400-820-3792

Inhibitors?ScreeningLibraries?Proteins

www.MedChemE

Donepezil-d7

Cat.No.:HY-W727525

CASNo.:1215071-00-3

Synonyms:E2020-dfreebase

7

分?式:C??H??D?NO?

分?量:386.54

作?靶点:Isotope-LabeledCompounds;Cholinesterase(ChE)

作?通路:Others;NeuronalSignaling

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Donepezil-d7(E2020-d7(freebase))是氘代标记的Donepezil.Donepezil(E2020freebase)是AChE抑制剂

，对?AChE和?AChE的IC50分别为8.12nM和11.6nM。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.