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Inhibitors?ScreeningLibraries?Proteins

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Diflunisal-13C6

Cat.No.:HY-18342S1

Synonyms:MK-647-13C6

分?式:C???C?H?F?O?

分?量:256.15

作?靶点:Isotope-LabeledCompounds;COX

作?通路:Others;Immunology/Inflammation

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Diflunisal-13C6(MK-647-13C6)是13C标记的Diflunisal.Diflunisal(MK-647)是?种?杨酸盐衍?物，具有?

甾体抗炎和尿酸舒缓性能，可单独?作?痛剂和类风湿关节炎患者。Diflunisal是环氧合酶(COX)的抑制剂。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.

[2].LinJH,etal.Dose-dependentpharmacokineticsofdiflunisalinrats:dualeffectsofproteinbindingandmetabolism.