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Dapagliflozin-13C6

Cat.No.:HY-10450S3

Synonyms:BMS-512148-13C6

分?式:C????C?H??ClO?

分?量:414.83

作?靶点:Isotope-LabeledCompounds

作?通路:Others

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Dapagliflozin-13C6(BMS-512148-13C6)是13C标记的Dapagliflozin.Dapagliflozin(BMS-512148)是?种竞

争性葡萄糖协同转运蛋?2(SGLT2)抑制剂，可导致尿液中葡萄糖的排泄，?于糖尿病(DM)的研究。

Dapagliflozin诱导HIF1表达并减轻肾脏IR损伤。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.