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CGP20712A(Standard)

Cat.No.:HY-101355BR

CASNo.:105737-62-0

Synonyms:CGP20712mesylate(Standard)

分?式:C??H??F?N?O?S

分?量:590.57

作?靶点:AdrenergicReceptor

作?通路:GPCR/GProtein;NeuronalSignaling

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性CGP20712A(Standard)是CGP20712A的分析标准品。本产品?于研究及分析应?。CGP20712A(CGP

20712mesylate)是?种?选择性β1-adrenoceptor拮抗剂，IC50为0.7nM，是对β2肾上腺素受体的选择

性约为10,000倍。

IC50TargetIC50:0.7nM(β1-adrenoceptor)[1]

REFERENCES

[1].DooleyDJ,etal.CGP20712A:ausefultoolforquantitatingbeta1-andbeta2-adrenoceptors.EurJPharmacol.1986Oct14;130(1-

2):137-9.

[2].KitagawaY,etal.Determinationofbeta-adrenoceptorsubtypeonratisolatedventricularmyocytesbyuseofhighlyselectivebeta-

antagonists.BrJPharmacol.1995Sep;116(1):1635-43.

[3].GrinoM,etal.Ontogenyofinsulin-inducedhypoglycemiastimulationofadrenocorticotropinsecretionintherat:roleofcatecholamines.