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Inhibitors?ScreeningLibraries?Proteins
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CDC20-IN-2
Cat.No.:HY-172401
分?式:C??H??Cl?F?N?O?S
分?量:701.26
作?靶点:APC;Apoptosis
作?通路:CellCycle/DNADamage;Apoptosis
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性CDC20-IN-2(14c)是Cdc20的抑制剂(KD:7.65μM)，导致G2/M期阻滞，促进DNA损伤积累，并稳定如
CyclinB1和Bim等关键底物，从?增强凋亡并抑制肿瘤细胞的增殖和迁移。
体外研究CDC20-IN-2(14c)exhibitsIC50valuesof3.28μMand23.86μMinMDA-MB-231andMCF10Acells,
respectively[1].
REFERENCES
[1].XiangyangLe,etal.Design,synthesisandoptimizationofApcinanaloguesasCdc20inhibitorsfortriple-negativebreastcancertherapy.
EurJMedChem.2025May5:289:117434.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
Forresearchuseonly.
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