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Inhibitors?ScreeningLibraries?Proteins

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Amprenavir-13C6

Cat.No.:HY-17430S2

Synonyms:VX-478-13C6

分?式:C????C?H??N?O?S

分?量:507.55

作?靶点:Isotope-LabeledCompounds;SARS-CoV;HIV;HIVProtease

作?通路:Others;Anti-infection;MetabolicEnzyme/Protease

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Amprenavir-13C6(VX-478-13C6)是13C标记的Amprenavir.Amprenavir(VX-478)是HIV蛋?酶抑制剂，Ki

为0.6nM。Amprenavir也是SARS-CoV3CLpro的抑制剂，IC50为1.09μM。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.

[2].QiSun,etal.Bardoxoloneandbardoxolonemethyl,twoNrf2activators