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文件名称：N-Desmethyl-clomipramine-d6-Desmethylclomipramine-d-sub-6-sub-生命科学试剂-MCE.pdf
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文档摘要

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Inhibitors?ScreeningLibraries?Proteins

www.MedChemE

N-Desmethylclomipramine-d6

Cat.No.:HY-12388S1

Synonyms:Desmethylclomipramine-d;Norclomipramine-d

66

分?式:C??H??D?ClN?

分?量:306.86

作?靶点:Isotope-LabeledCompounds;DrugMetabolite

作?通路:Others;MetabolicEnzyme/Protease

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性N-Desmethylclomipramine-d6(Desmethylclomipramine-d6)是氘代标记的N-Desmethylclomipramine.

Desmethylclomipramine(Norclomipramine)是Clomipramine(HY-B0457A)的代谢产物，可?于神经学研究

[1]。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofP