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Inhibitors?ScreeningLibraries?Proteins
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PDE10A-IN-5
Cat.No.:HY-173360
分?式:C??H??N?O?
分?量:514.62
作?靶点:Phosphodiesterase(PDE)
作?通路:MetabolicEnzyme/Protease
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性PDE10A-IN-5(CompoundA30)是?种具有?服活性的磷酸?酯酶10A(PDE10A)的抑制剂，IC50值为3.5
nM。PDE10A-IN-5通过抑制PDE10A，激活环磷酸腺苷(cAMP)相关信号通路，从?发挥抑制肺?管重塑的活
性，可?于肺动脉?压领域的研究[1]。
IC50TargetPDE10A
3.5nM(IC50)
REFERENCES
[1].HuangH,etal.Discoveryofnovelazetidine-basedimidazopyridinesasselectiveandorallybioavailableinhibitorsofphosphodiesterase
10Aforthetreatmentofpulmonaryarterialhypertension.EurJMedChem.2025Jun5;290:117537.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
Forresearchuseonly.
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