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Hotline:400-820-3792

Inhibitors?ScreeningLibraries?Proteins

www.MedChemE

BET-IN-28

Cat.No.:HY-170226

分?式:C??H??N?O?

分?量:499.57

作?靶点:EpigeneticReaderDomain

作?通路:Epigenetics

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性BET-IN-28(Compound44)是溴结构域和末端外结构域(BET)的强效抑制剂，对BRD4-BD1的IC50值为4.47

nM。BET-IN-28可阻断BET蛋?与组蛋?尾部N-?酰化赖氨酸残基的相互作?，下调特定基因表达。BET-IN-

28可?于?液系统恶性肿瘤和实体瘤研究[1]。

REFERENCES

[1].ZaidiJM,etal.DiscoveryofHighlyPotentBETInhibitorsbasedonaTractableTricyclicScaffold.ACSMedChemLett.2025Mar

21;16(4):588-595.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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1/1MasterofBioactiveMolecules—您?边的抑制剂?师