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Tezacaftor-d6

Cat.No.:HY-15448S1

CASNo.:1961280-94-3

Synonyms:VX-661-d6

分?式:C??H??D?F?N?O?

分?量:526.53

作?靶点:Isotope-LabeledCompounds;CFTR

作?通路:Others;MembraneTransporter/IonChannel

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Tezacaftor-d6(VX-661-d6)是氘代标记的Tezacaftor.Tezacaftor(VX-661)是?种F508delCFTR校正?。它有

助于CFTR蛋?到达细胞表?。然?，Ivacaftor(VX-770，HY-13017)这种CFTR增效剂，有助于延长细胞表

?CFTR蛋?通道的开放时间。Tezacaftor与Ivacaftor结合，显?出对囊性纤维化和CFTRPhe508del突变纯

合?疾病的有?效果。此外，Elexacaftor(VX-445，HY-111772)也是?种CFTR校正器。Elexacaftor-

Tezacaftor-Ivacaftor针对?少有?个Phe508del突变的囊性纤维化（CF），通常可避免肺移植适应症。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.

[2].TreatmentwithVX-661andIvacaftori