基本信息
文件名称：Sacubitrilat-13C4-Desethyl-Sacubitril-sup-13-sup-C-sub-4-sub-生命科学试剂-MCE.pdf
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更新时间：2025-05-21
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文档摘要

Hotline:400-820-3792

Inhibitors?ScreeningLibraries?Proteins

www.MedChemE

Sacubitrilat-13C4

Cat.No.:HY-W747097

Synonyms:DesethylSacubitril-13C;LBQ-657-13C

44

分?式:C????C?H??NO?

分?量:387.41

作?靶点:Isotope-LabeledCompounds;Neprilysin

作?通路:Others;MetabolicEnzyme/Protease

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Sacubitrilat-13C4(DesethylSacubitril-13C4)是13C标记的Sacubitrilat.Sacubitrilat(DesethylSacubitril)是

?种活性的脑啡肽酶(NEP)抑制剂。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.

[2].SchieringN,