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Inhibitors?ScreeningLibraries?Proteins
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PLK1-IN-14
Cat.No.:HY-173233
分?式:C??H??F?N?O?
分?量:802.92
作?靶点:Polo-likeKinase(PLK)
作?通路:CellCycle/DNADamage
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性PLK1-IN-14(CompoundHit-4)是?种选择性PLK1抑制剂，对PLK1的IC50为22.61pM，对DU-145前列腺
癌细胞增殖的IC50为0.09nM。PLK1-IN-14可?于前列腺癌的研究[1]。
IC50TargetPLK1
22.61pM(IC50)
REFERENCES
[1].XuZ,etal.DiscoveryofanovelPLK1inhibitorwithhighinhibitorypotencyusingacombinedvirtualscreeningstrategy.JEnzymeInhib
MedChem.2025Dec;40(1):2467798.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
Forresearchuseonly.
Tel:400-820-3792;021Fax:021E-mail:tech@MedChemE
1/1MasterofBioactiveMolecules—您?边的抑制剂?师