Hotline:400-820-3792
Inhibitors?ScreeningLibraries?Proteins
www.MedChemE
Elinzanetant-d3
Cat.No.:HY-109171S
Synonyms:NT-814-d;BAY3427080-d
33
分?式:C??H??D?F?N?O?
分?量:671.66
作?靶点:Isotope-LabeledCompounds;NeurokininReceptor
作?通路:Others;GPCR/GProtein;NeuronalSignaling
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性Elinzanetant-d3(NT-814-d3)是氘代标记的Elinzanetant.Elizanetant(NT-814)是?种具有?服活性的、选择
性NK-1,3受体拮抗剂。Elizanetant能够降低雌?醇和黄体酮?平,?于?性更年期相关的?管运动症状、睡
眠障碍等研究。
体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,
largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention
becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.
REFERENCES
[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-