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Inhibitors?ScreeningLibraries?Proteins
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OM-7D3-B3
Cat.No.:HY-P991200
作?靶点:Claudin;HCV
作?通路:Anti-infection
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性OM-7D3-B3是?种单克隆抗体，靶向?紧密连接蛋?1(CLDN1)(Kd=4nM)。OM-7D3-B3阻断CLDN1参与
丙型肝炎病毒(HCV)进?细胞的过程。OM-7D3-B3有望?于HCV感染的研究[1][2]。
IC50TargetClaudin-1
4nM(Kd)
REFERENCES
[1].FofanaI,etal.Monoclonalanti-claudin1antibodiespreventhepatitisCvirusinfectionofprimaryhumanhepatocytes.Gastroenterology.
2010Sep;139(3):953-64,964.e1-4.
[2].HashimotoY,etal.Claudin-targeteddrugdevelopmentusinganti-claudinmonoclonalantibodiestotreathepatitisandcancer.AnnNY
AcadSci.2017Jun;1397(1):5-16.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
Forresearchuseonly.
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